New drug to treat muscular dystrophy based on U of A research

Created using synthetic DNA, viltolarsen is an excellent example of precision medicine

New drug to treat muscular dystrophy based on U of A researchA University of Alberta researcher’s past work has led to a new drug being approved for use in the United States to treat patients suffering from Duchenne muscular dystrophy (DMD). The drug, viltolarsen, was approved for use in Japan earlier this year and passed a significant hurdle in August when the U.S. Food and Drug…

Antiviral drug remdesivir offers second mechanism of attack

Understanding how the conditionally approved COVID-19 drug works is key to improving treatments, says U of A researcher

Antiviral drug remdesivir offers second mechanism of attackResearchers at the University of Alberta have discovered a novel, second mechanism of action by the antiviral drug remdesivir against SARS-CoV-2, according to findings published in the Journal of Biological Chemistry. The research team previously demonstrated how remdesivir inhibits the COVID-19 virus’s polymerase or replication machinery in a test tube. Matthias Götte, chair of medical microbiology and immunology…

Little evidence vitamin D prevents severe COVID-19

Getting too much vitamin D can also cause health problems, says U of A pediatric kidney specialist

Little evidence vitamin D prevents severe COVID-19At the beginning of May, a pair of studies emerged suggesting people who are deficient in vitamin D are more likely to experience serious health complications if infected with COVID-19. Sales of the micronutrient soared as a scared public tried to gain any advantage they could over the virus. Unfortunately, University of Alberta pediatrics professor Todd…

Protein causes mutations that lead to breast cancer cell aggression

U of A researcher uncovers new mechanism for why a particular biomarker is linked with poor outcomes in certain patients

Protein causes mutations that lead to breast cancer cell aggressionLike most scientists, University of Alberta biochemist Ing Swie Goping is curious. When her team discovered that a protein was associated with poor outcomes in breast cancer patients, she wanted to know why. Now, that curiosity has led to the discovery of a new mechanism for how certain breast cancers develop, which could one day…

Researchers develop tool to help build better prosthetic limbs

U of A neuroscientists look into the complex physical and mental co-ordination needed for seemingly simple movements

Researchers develop tool to help build better prosthetic limbsProsthetic users have to look longer at the object they’re interacting with than their able-bodied counterparts, according to University of Alberta research that illustrates just one of the intricacies involved in devising the next generation of prosthetic limbs. “There are prosthetic devices becoming available that are almost indistinguishable from real limbs, but the real problem…

Get science out of the lab and onto the street to save lives

We know good safety practices from our grandmother – but are we courageous and persistent enough to follow them?

Get science out of the lab and onto the street to save livesBy Derek Ng, Deborah Prabhu and Allan Bonner Contributors It seems as if everyone is an epidemiologist these days. So it’s worth considering epidemiology’s history and the role it should be playing in public policy, preventing disease and promoting health. When U.S. President Donald Trump and reporters get into arguments about infections, testing and death…